참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-Methoxy-4-Methylphenol | HCID 7144 | — |
| 반응물 | 1,3-Dibromopropane | HCID 8001 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 1-(3-Bromo-propoxy)-2-methoxy-4-methyl-benzene | HCID 43135428 | 42.1% |
반응 단계
To a solution of 2-methoxy-4-methylphenol (500 mg, 3.62 mmol) in acetonitrile (20 mL) was added 1,3-dibromopropane (3.65 g, 201.89 mmol) followed by cesium carbonate (2.35 g, 7.24 mmol). The resulting solution was heated at 85° C. for 48 h, then cooled to rt. The solution was filtered through a Celite® pad. The Celite® was washed with acetone, and the combined filtrates were concentrated under reduced pressure to give the title compound as a white solid (395 mg, 42%). GC/MS (EI) m/z 258 (M)+, RT 7.94 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07592361B2 |
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| 출처 데이터셋 | uspto-grants-2009_09 |
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| ORD ID | ord-376c3a1649d241508d7d643ee1f16ae9 |
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| 출처 메모 | uspto-grants-2009_09 |
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