Cesium carbonate → {2-[1-(2,3-Dimethylphenyl)ethyl]-1h-imidazol-1-yl}methyl propionate

HRID 734452

반응식

HRID 734452 반응식
[CH3:1][C:2]1[C:7]([CH3:8])=[CH:6][CH:5]=[CH:4][C:3]=1[CH:9]([C:11]1[NH:12][CH:13]=[CH:14][N:15]=1)[CH3:10].C(=O)([O-])[O-].[Cs+].[Cs+].[C:22]([O:26][CH2:27]Cl)(=[O:25])[CH2:23][CH3:24]>CC(C)=O>[C:22]([O:26][CH2:27][N:15]1[CH:14]=[CH:13][N:12]=[C:11]1[CH:9]([C:3]1[CH:4]=[CH:5][CH:6]=[C:7]([CH3:8])[C:2]=1[CH3:1])[CH3:10])(=[O:25])[CH2:23][CH3:24]

참가 물질

5

반응물 3

HCID 10796Cesium carbonateHCID 221144Chloromethyl propionateHCID 216625422-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole

생성물 1

HCID 24738940{2-[1-(2,3-Dimethylphenyl)ethyl]-1h-imidazol-1-yl}methyl propionate

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

To a suspension of the compound of Example 1 (120 mg, 0.6 mmol) and caesium carbonate (731 mg, 1.8 mmol) in acetone (4 ml), under nitrogen, was added chloromethyl propionate (Eur. J. Pharm. Sci: 24; 5; 2005; 433-440, 183 mg, 1.5 mmol) and the reaction mixture was stirred at room temperature for 18 h. The mixture was filtered and the filtrate was concentrated in vacuo.

후처리

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-87da69cc771e476499aa674037b88290
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07592362B2

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