Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cesium carbonate → 1-[3-(benzyloxy)benzyl]-2-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1h-imidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 3-Benzyloxybenzyl bromide | HCID 1502047 | — |
| 반응물 | Demiditraz | HCID 24738933 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | 1-[3-(benzyloxy)benzyl]-2-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1h-imidazole | HCID 57718416 | — |
반응 단계
To a mixture of the compound of Example 58 (90 mg, 0.45 mmol) and caesium carbonate (244 mg, 0.75 mmol) in 1-methyl-2-pyrrolidinone (1 ml) was added 1-(benzyloxy)-3-(bromomethyl)benzene (139 mg, 0.50 mmol). The reaction mixture was stirred at room temperature for 48 h and then filtered through a Whatman PTFE filter tube (5 μm).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07592362B2 |
| 출처 데이터셋 | uspto-grants-2009_09 |
| ORD ID | ord-2e13b1e069554b41bf6b9d939244af14 |
| 출처 메모 | uspto-grants-2009_09 |