Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → Ethyl 2-(3-(2,6-difluorobenzyloxy)phenyl)acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Ethyl (3-Hydroxyphenyl)acetate | HCID 572437 | — |
| 반응물 | 2-(Bromomethyl)-1,3-difluorobenzene | HCID 581435 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Ethyl 2-(3-(2,6-difluorobenzyloxy)phenyl)acetate | HCID 66875326 | — |
반응 단계
To a stirred solution of Ethyl 2-(3-hydroxyphenyl)acetate (4 g, 22.2 mmol) in DMF (20 ml) was added potassium carbonate (4 g, 28.9 mmol) at room temperature followed by drop wise addition of 2,6-Difluorobenzyl bromide (5.06 g, 24.4 mmol). The reaction mixture was stirred for 12 hours and taken in ethyl acetate, washed with water (2×), brine, dried over Na2SO4, filtered, concentrated and purified by flash chromatography on a silica gel column (hex:ethyl acetate 4:1) to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829058B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-2ee651f412704a40bed080bb95e0af14 |
| 출처 메모 | uspto-grants-2014_09 |