Potassium Carbonate → Ethyl 2-(3-(4-(trifluoromethyl)benzyloxy)phenyl)acetate

참여 물질

역할	이름	HCID	투입량
반응물	Potassium Carbonate	HCID 11430	—
반응물	1-(Bromomethyl)-4-(trifluoromethyl)benzene	HCID 123062	—
반응물	Ethyl (3-Hydroxyphenyl)acetate	HCID 572437	—
용매	Dimethylformamide	HCID 6228	—
용매	Ethyl Acetate	HCID 8857	—
생성물	Ethyl 2-(3-(4-(trifluoromethyl)benzyloxy)phenyl)acetate	HCID 11974618	—

반응 단계

To a stirred solution of Ethyl 2-(3-hydroxyphenyl)acetate (7.3 g, 30.5 mmol) in DMF (20 ml) was added potassium carbonate (5.47 g, 39.6 mmol) at room temperature followed by drop wise addition of 4-Trifluoromethylbenzyl bromide (6.04 g, 33.6 mmol). The reaction mixture was stirred for 12 hours and taken in ethyl acetate, washed with water (2×), brine, dried over Na2SO4, filtered, concentrated and purified by flash chromatography on a silica gel column (hex:ether 5:1) to give the title compound.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08829058B2
출처 데이터셋	uspto-grants-2014_09
ORD ID	ord-4d3e1724736d422eb437a7f180dce3b5
출처 메모	uspto-grants-2014_09