(2-Hydroxyphenyl)acetic acid → 2-(2-Hydroxyphenyl)acetic acid ethyl ester
반응식
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=[O:10].O.[C:13]1(C)C=CC(S(O)(=O)=O)=C[CH:14]=1>C(O)C>[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([O:11][CH2:13][CH3:14])=[O:10]참가 물질
4
실험 절차
The stirred solution of 2-(2-Hydroxyphenyl)acetic acid (10 g, 65.7 mmol) and p-Toluenesulfonic acid monohydrate (1.40 g, 7.3 mmol) in abs ethanol (100 ml) was refluxed for 4 hours or until all the starting material is consumed. The reaction mixture was concentrated, diluted with ethyl acetate and washed with 1M HCl and brine. The organic layer was dried over Na2SO4, filtered, concentrated, and purified by flash chromatography on a silica gel column (hex:ethyl acetate 2:1) to give the title compound.
후처리
- customis consumed
- concentrationThe reaction mixture was concentrated
- additiondiluted with ethyl acetate
- washwashed with 1M HCl and brine
- dry with materialThe organic layer was dried over Na2SO4
- filtrationfiltered
- concentrationconcentrated
- custompurified by flash chromatography on a silica gel column (hex:ethyl acetate 2:1)
출처 및 근거
- ORD 기록
- ord-3444b0344ac24d3e987a63805847d5ac
- 출처 데이터셋
- uspto-grants-2014_09
- 특허 번호
- US08829058B2
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