Methanol → HCID 13318612, 화합물

HRID 734730노트

반응식

HRID 734730 반응식
[NH2:1][S:2]([C:5]1[C:6]([Cl:15])=[CH:7][C:8]([F:14])=[C:9]([CH:13]=1)[C:10]([OH:12])=[O:11])(=[O:4])=[O:3].[CH3:16]O>S(=O)(=O)(O)O.CCOC(C)=O>[NH2:1][S:2]([C:5]1[C:6]([Cl:15])=[CH:7][C:8]([F:14])=[C:9]([CH:13]=1)[C:10]([O:12][CH3:16])=[O:11])(=[O:3])=[O:4]

참가 물질

5

반응물 2

HCID 887MethanolHCID 124625724-Chloro-2-fluoro-5-sulfamoylbenzoic acid

생성물 1

HCID 13318612HCID 13318612, 화합물수율 95%

시약·촉매·용매 2

HCID 1118Sulfuric Acid촉매HCID 8857Ethyl Acetate용매

실험 절차

5-(Aminosulfonyl)-4-chloro-2-fluorobenzoic acid (507 mg, 2.0 mmol) in CH3OH (3 mL) with 3 drops of concentrated sulfuric acid was heated at 80° C. for 60 hours. The reaction mixture was diluted with EtOAc (20 mL), washed with water, brine, and dried (Na2SO4). The solvent was evaporated to afford the product (508 mg, 95%) as a white solid. MS (ES+) m/z 268 [M+H]+.

후처리

  1. washwashed with water, brine
  2. dry with materialdried (Na2SO4)
  3. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-6b6ebbc1a3f14e38b56bd92dc5659ec0
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07592357B2

반응 노트

불러오는 중…