HCID 68817418, 화합물 → HCID 86068765, 화합물

HRID 734732노트

반응식

HRID 734732 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([CH2:9][OH:10])=[CH:4][C:3]=1[S:11]([NH2:14])(=[O:13])=[O:12]>CC(C)=O.O=[Mn]=O>[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([CH:9]=[O:10])=[CH:4][C:3]=1[S:11]([NH2:14])(=[O:12])=[O:13]

참가 물질

4

반응물 1

HCID 68817418HCID 68817418, 화합물

생성물 1

HCID 86068765HCID 86068765, 화합물수율 60.1%

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 180Acetone용매

실험 절차

A solution of 2-chloro-4-fluoro-5-(hydroxymethyl)benzenesulfonamide (440 mg, 1.84 mmol) in acetone (18 mL) was added to a round bottom flask containing MnO2 (1.60 g, 18.4 mmol). The mixture was stirred for 50 hours until the starting material was gone, then filtered though a pad of celite. The filtrate was evaporated to afford the product (263 mg, 60%) as a white solid. MS (ES+) m/z 238 [M+H]+.

후처리

  1. filtrationfiltered though a pad of celite
  2. customThe filtrate was evaporated

출처 및 근거

ORD 기록
ord-400fce3e29ec4fe1807fbf20fa15f281
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07592357B2

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