Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → Methyl 4-chloro-3-sulfamoylbenzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | 4-Chloro-3-sulfamoylbenzoic acid | HCID 14568 | — |
| 촉매 | Sulfuric Acid | HCID 1118 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Methyl 4-chloro-3-sulfamoylbenzoate | HCID 4277179 | 95% |
반응 단계
3-(Aminosulfonyl)-4-chlorobenzoic acid (943 mg, 4.0 mmol) was heated at 70° C. in CH3OH (10 mL) with 3 drops of concentrated sulfuric acid for 34 hours. The reaction mixture was diluted with EtOAc (20 mL), washed with water, brine, and dried (Na2SO4). The solvent was evaporated to afford the product (950 mg, 95%) as a white solid. MS (ES+) m/z 250 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07592357B2 |
| 출처 데이터셋 | uspto-grants-2009_09 |
| ORD ID | ord-2ba078ff6fe9468996bc53adcbb229cd |
| 출처 메모 | uspto-grants-2009_09 |