Methanol → Benzoic acid, 3-(aminosulfonyl)-, methyl ester

HRID 734736

반응식

HRID 734736 반응식
[NH2:1][S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([OH:10])=[O:9])(=[O:4])=[O:3].[CH3:14]O>S(=O)(=O)(O)O.CCOC(C)=O>[NH2:1][S:2]([C:5]1[CH:6]=[C:7]([CH:11]=[CH:12][CH:13]=1)[C:8]([O:10][CH3:14])=[O:9])(=[O:3])=[O:4]

참가 물질

5

반응물 2

HCID 887MethanolHCID 2293523-Sulfamoylbenzoic acid

생성물 1

HCID 108836Benzoic acid, 3-(aminosulfonyl)-, methyl ester수율 98%

시약·촉매·용매 2

HCID 1118Sulfuric Acid촉매HCID 8857Ethyl Acetate용매

실험 절차

3-(Aminosulfonyl)benzoic acid (603 mg, 3.0 mmol) was heated at 80° C. in CH3OH (3 mL) with 3 drops of concentrated sulfuric acid for 60 hours. The reaction mixture was diluted with EtOAc (20 mL), washed with water, brine, and dried (Na2SO4). The solvent was evaporated to afford the product (630 mg, 98%) as a white solid. MS (ES+) m/z 216 [M+H]+.

후처리

  1. washwashed with water, brine
  2. dry with materialdried (Na2SO4)
  3. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-a4b72a81d93e43e8aa724688c2f86acf
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07592357B2

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