Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Amino-5-bromopyrazine → 5-(2,4-Dichlorophenyl)pyrazin-2-ylamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Amino-5-bromopyrazine | HCID 599539 | — |
| 반응물 | 2,4-Dichlorophenylboric acid | HCID 21984477 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 5-(2,4-Dichlorophenyl)pyrazin-2-ylamine | HCID 22249088 | — |
반응 단계
The product was prepared analogously to Example 48.1a from 1.74 g (10.0 mmol) of 5-bromopyrazin-2-ylamine and 1.91 g (10.0 mmol) of 2,4-dichlorophenylboric acid. Yield: 800 mg (33% of theoretical); C10H7Cl2N3 (M=240.088); calc.: molpeak (M+H)+240/242/244 (2 Cl); found: molpeak (M+H)+:240/242/244 (2 Cl); Rf value: 0.35 (silica gel, PE/EtOAc 7:3).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07592358B2 |
| 출처 데이터셋 | uspto-grants-2009_09 |
| ORD ID | ord-41eca724a3374b0c8058ee92855dd827 |
| 출처 메모 | uspto-grants-2009_09 |