2-Amino-5-bromopyrazine → 5-(2,4-Dichlorophenyl)pyrazin-2-ylamine

HRID 734883

반응식

HRID 734883 반응식
Br[C:2]1[N:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1.[Cl:9][C:10]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:11]=1OB(O)O>CCOC(C)=O>[Cl:9][C:10]1[CH:15]=[C:14]([Cl:16])[CH:13]=[CH:12][C:11]=1[C:2]1[N:3]=[CH:4][C:5]([NH2:8])=[N:6][CH:7]=1

참가 물질

4

반응물 2

HCID 5995392-Amino-5-bromopyrazineHCID 219844772,4-Dichlorophenylboric acid

생성물 1

HCID 222490885-(2,4-Dichlorophenyl)pyrazin-2-ylamine

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

The product was prepared analogously to Example 48.1a from 1.74 g (10.0 mmol) of 5-bromopyrazin-2-ylamine and 1.91 g (10.0 mmol) of 2,4-dichlorophenylboric acid. Yield: 800 mg (33% of theoretical); C10H7Cl2N3 (M=240.088); calc.: molpeak (M+H)+240/242/244 (2 Cl); found: molpeak (M+H)+:240/242/244 (2 Cl); Rf value: 0.35 (silica gel, PE/EtOAc 7:3).

출처 및 근거

ORD 기록
ord-41eca724a3374b0c8058ee92855dd827
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07592358B2

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