홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Potassium Carbonate → N-(5-{3-[(1-methyl-1H-pyrazol-3-yl)amino]-6-quinoxalinyl}-3-pyridinyl)benzenesulfonamide

HRID 734970
노트
인쇄 미리보기

반응식

HRID 734970 반응식
Br[C:2]1[CH:11]=[C:10]2[C:5]([N:6]=[CH:7][C:8]([NH:12][C:13]3[CH:17]=[CH:16][N:15]([CH3:18])[N:14]=3)=[N:9]2)=[CH:4][CH:3]=1.CC1(C)C(C)(C)OB([C:27]2[CH:28]=[C:29]([NH:33][S:34]([C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)(=[O:36])=[O:35])[CH:30]=[N:31][CH:32]=2)O1.C(=O)([O-])[O-].[K+].[K+]>O1CCOCC1>[CH3:18][N:15]1[CH:16]=[CH:17][C:13]([NH:12][C:8]2[CH:7]=[N:6][C:5]3[C:10]([N:9]=2)=[CH:11][C:2]([C:27]2[CH:28]=[C:29]([NH:33][S:34]([C:37]4[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=4)(=[O:35])=[O:36])[CH:30]=[N:31][CH:32]=2)=[CH:3][CH:4]=3)=[N:14]1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 52936632N-[5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl]benzenesulfonamideHCID 685082717-bromo-N-(1-methyl-1H-pyrazol-3-yl)-2-quinoxalinamine

생성물 1

HCID 57843502N-(5-{3-[(1-methyl-1H-pyrazol-3-yl)amino]-6-quinoxalinyl}-3-pyridinyl)benzenesulfonamide수율 47.9%

시약·촉매·용매 1

HCID 31275
1,4-Dioxane
용매

실험 절차

A slurry of 7-bromo-N-(1-methyl-1H-pyrazol-3-yl)-2-quinoxalinamine (0.37 mmol), N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]benzenesulfonamide (0.55 mmol), and [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) dichloromethane complex (1:1) (0.03 mmol) in 1,4-dioxane (4 ml) and 2M solution potassium carbonate (2 ml) was stirred at 100° C. for 2 hours. The reaction was cooled to ambient temperature, separated the organic layer and purified directly on silica by column chromatography (10% methanol/ethyl acetate). The desired fractions were combined and concentrated to give the title compound (81 mg, 32%) as a pale green solid. MS(ES)+ m/e 458.1 [M+H]+.

후처리

  1. customseparated the organic layer
  2. custompurified directly on silica by column chromatography (10% methanol/ethyl acetate)
  3. concentrationconcentrated

출처 및 근거

ORD 기록
ord-1513a8fc916645e39a04f0f2d5de7053
출처 데이터셋
uspto-grants-2009_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07592342B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트