Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
{4-[2-(Diethylamino)ethoxy]phenyl}methanamine → 3-(2-Chloro-4-methylphenyl)propynoic acid-[4-(2-diethylaminoethoxy)phenyl]methylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | {4-[2-(Diethylamino)ethoxy]phenyl}methanamine | HCID 235944 | — |
| 반응물 | (2-Chloro-4-trifluoromethylphenyl)propynoic acid | HCID 68817422 | — |
| 용매 | Dichloromethane methanol | HCID 21226129 | — |
| 생성물 | 3-(2-Chloro-4-methylphenyl)propynoic acid-[4-(2-diethylaminoethoxy)phenyl]methylamide | HCID 68816196 | — |
반응 단계
Prepared analogously to Example 2.3.f. from [4-(2-diethylaminoethoxy)phenyl]methylamine and (2-chloro-4-trifluoromethylphenyl)propynoic acid. Yield: 60 mg (22% of theory); melting point: 135° C.-138° C.; C23H24ClF3N2O2 (M=452.90); calc.: molecular ion peak (M+H)+: 453/455; found: molecular ion peak (M+H)+: 453/455; Rf value: 0.4 (silica gel, dichloromethane/methanol (9:1)).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07592373B2 |
| 출처 데이터셋 | uspto-grants-2009_09 |
| ORD ID | ord-00ab607748f4433d9ace12dca0689b73 |
| 출처 메모 | uspto-grants-2009_09 |