Dichloromethane methanol → [2-(3-Chloro-4-aminophenoxy)ethyl]diethylamine

HRID 735092노트

반응식

HRID 735092 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][C:15]=1[N+:16]([O-])=O)[O:5][CH2:6][CH2:7][N:8]([CH2:11][CH3:12])[CH2:9][CH3:10].ClCCl.CO>C(OCC)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([CH:13]=[CH:14][C:15]=1[NH2:16])[O:5][CH2:6][CH2:7][N:8]([CH2:9][CH3:10])[CH2:11][CH3:12]

참가 물질

4

반응물 2

HCID 21226129Dichloromethane methanolHCID 68816613[2-(3-Chloro-4-nitrophenoxy)ethyl]diethylamine

생성물 1

HCID 57082476[2-(3-Chloro-4-aminophenoxy)ethyl]diethylamine

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Prepared analogously to Example 3.1.b. from [2-(3-chloro-4-nitrophenoxy)ethyl]diethylamine in ethyl acetate. Yield: 1.05 g (95.4% of theory); C12H19ClN2O (M=242.75); calc.: molecular ion peak (M+H)+: 243/245; found: molecular ion peak (M+H)+: 243/245; Rf value: 0.41 (silica gel, dichloromethane/methanol (90:10)).

후처리

  1. customPrepared analogously to Example 3.1.b

출처 및 근거

ORD 기록
ord-df9a410578e54743acc37b864927a314
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07592373B2

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