참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Diisopropyl Ether | HCID 7914 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | 2-(Chloromethyl)-5-nitro-1,3-benzoxazole | HCID 2764189 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 5-Nitro-2-pyrrolidin-1-ylmethylbenzoxazole | HCID 59766992 | — |
반응 단계
A reaction mixture of 3 g (14.11 mmol) of 2-chloromethyl-5-nitrobenzoxazole, 1.5 mL (17.97 mmol) of pyrrolidine, and 3.9 g (28.22 mmol) of potassium carbonate in 30 mL of DMF is stirred for 4 hours at 50° C. Then the reaction mixture is diluted with water and covered with diisopropyl ether, The precipitated yellow solid is suction filtered, washed again, and dried in the circulating air dryer at 60° C. Yield: 1.8 g (52% of theory); C12H13N3O3 (M=247.25); calc.: molecular ion peak (M+H)+: 248; found: molecular ion peak (M+H)+: 248; Rf value: 0.4 (silica gel, dichloromethane/ethanol (20:1)).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07592373B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_09 |
|---|
| ORD ID | ord-652e8ce8327f40859f9e5f8de2b56507 |
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| 출처 메모 | uspto-grants-2009_09 |
|---|
