Piperidine → 1-(2-Chloro-4-nitrobenzyl)piperidine

반응식

[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:7][C:8]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:9]=1[CH2:10]Cl>>[Cl:7][C:8]1[CH:15]=[C:14]([N+:16]([O-:18])=[O:17])[CH:13]=[CH:12][C:9]=1[CH2:10][N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

반응물 2

HCID 8082Piperidine

HCID 3016511alpha,2-Dichloro-4-nitrotoluene

생성물 1

HCID 688193431-(2-Chloro-4-nitrobenzyl)piperidine

실험 절차

Prepared analogously to Example 4.29.a. from 4 mL (40 mmol) of piperidine and 2 g (9.71 mmol) of 2-chloro-4-nitrobenzylchloride. Yield: 2.39 g (97% of theory); C12H15ClN2O2 (M=254.71); calc.: molecular ion peak (M+H)+: 255/257 (Cl); found: molecular ion peak (M+H)+: 255/257 (Cl); Rf value: 0.32 (silica gel, petroleum ether/ethyl acetate (6:1)).

후처리

customPrepared analogously to Example 4.29.a

출처 및 근거

ORD 기록: ord-36a26e61ae2b46ae9fafde6d6e199282
출처 데이터셋: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07592373B2

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