HCID 22185405, 화합물 → HCID 57845855, 화합물

HRID 735138노트

반응식

HRID 735138 반응식
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:4][C:3]=1[C:12]#[C:13][C:14]([OH:16])=O.[CH3:17][O:18][C:19]1[CH:20]=[C:21]([NH2:34])[CH:22]=[CH:23][C:24]=1[O:25][CH2:26][CH2:27][N:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>ClCCl.CO>[CH3:17][O:18][C:19]1[CH:20]=[C:21]([NH:34][C:14](=[O:16])[C:13]#[C:12][C:3]2[CH:4]=[CH:5][C:6]([C:8]([F:9])([F:10])[F:11])=[CH:7][C:2]=2[Cl:1])[CH:22]=[CH:23][C:24]=1[O:25][CH2:26][CH2:27][N:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1

참가 물질

4

반응물 2

HCID 22185405HCID 22185405, 화합물HCID 68817422(2-Chloro-4-trifluoromethylphenyl)propynoic acid

생성물 1

HCID 57845855HCID 57845855, 화합물

시약·촉매·용매 1

HCID 21226129Dichloromethane methanol용매

실험 절차

Prepared analogously to Example 2.3.f. from (2-chloro-4-trifluoromethylphenyl)propynoic acid and 3-methoxy-4-(2-morpholin-4-ylethoxy)phenylamine. Yield: 20 mg (6.9% of theory); melting point: 209° C.-211° C.; C23H22ClF3N2O4 (M=482.89); calc.: molecular ion peak (M+H)+: 483/485; found: molecular ion peak (M+H)+: 483/485; Rf value: 0.5 (silica gel, dichloromethane/methanol (9:1)).

후처리

  1. customPrepared analogously to Example 2.3.f

출처 및 근거

ORD 기록
ord-909f457a1d9d4ada93bcb1dff258ad20
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07592373B2

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