Tetrabutylammonium Fluoride → 3-Bromo-4-ethynylbiphenyl

HRID 735157노트

반응식

HRID 735157 반응식
[F-].C([N+](CCCC)(CCCC)CCCC)CCC.[Br:19][C:20]1[CH:21]=[C:22]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[CH:23]=[CH:24][C:25]=1[C:26]#[C:27][Si](C(C)(C)C)(C)C>C1COCC1>[Br:19][C:20]1[CH:21]=[C:22]([C:35]2[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=2)[CH:23]=[CH:24][C:25]=1[C:26]#[CH:27]

참가 물질

4

반응물 2

HCID 2724141Tetrabutylammonium FluorideHCID 68817863(3-Bromobiphenyl-4-ylethynyl)-tert-butyldimethylsilane

생성물 1

HCID 860607363-Bromo-4-ethynylbiphenyl

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

1.99 mL (1.99 mmol) of a 1M tetrabutylammonium fluoride solution in THF is added batchwise at 5° C. to a solution of 495 mg (1.33 mmol) of (3-bromobiphenyl-4-ylethynyl)-tert-butyldimethylsilane in 8 mL of anhydrous THF. The reaction mixture is stirred for another 30 minutes at ambient temperature and evaporated down. The residue is combined with diethyl ether and water and the organic phase is dried over sodium sulfate. Yield: 0.34 g (99% of theory); C14H9Br (M=257.12); calc.: molecular ion peak (M−H)−: 255/257 (Br); found: molecular ion peak (M−H)−: 255/257 (Br).

후처리

  1. customevaporated down
  2. dry with materialthe organic phase is dried over sodium sulfate

출처 및 근거

ORD 기록
ord-ce0087346a914ada91830205f2a9702d
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07592373B2

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