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Ethanol, 2-(cyclohexylamino)- → (E)-N-(4'-chlorobiphenyl-4-yl)-3-(4-{[cyclohexyl-(2-hydroxyethyl)amino]methyl}phenyl)acrylamide

HRID 735180
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반응식

HRID 735180 반응식
[CH:1]1([NH:7][CH2:8][CH2:9][OH:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:23]=[CH:22][C:21]([NH:24][C:25](=[O:36])/[CH:26]=[CH:27]/[C:28]3[CH:33]=[CH:32][C:31]([CH2:34]Cl)=[CH:30][CH:29]=3)=[CH:20][CH:19]=2)=[CH:14][CH:13]=1>CN(C=O)C>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]2[CH:19]=[CH:20][C:21]([NH:24][C:25](=[O:36])/[CH:26]=[CH:27]/[C:28]3[CH:29]=[CH:30][C:31]([CH2:34][N:7]([CH:1]4[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]4)[CH2:8][CH2:9][OH:10])=[CH:32][CH:33]=3)=[CH:22][CH:23]=2)=[CH:14][CH:13]=1
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참가 물질

4

반응물 2

HCID 17827Ethanol, 2-(cyclohexylamino)-HCID 68816418(E)-N-(4'-chlorobiphenyl-4-yl)-3-(4-chloromethylphenyl)acrylamide

생성물 1

HCID 57845786(E)-N-(4'-chlorobiphenyl-4-yl)-3-(4-{[cyclohexyl-(2-hydroxyethyl)amino]methyl}phenyl)acrylamide

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

0.24 g (1.7 mmol) of 2-cyclohexylaminoethanol are added to a suspension of 130 mg (0.34 mmol) of (E)-N-(4′-chlorobiphenyl-4-yl)-3-(4-chloromethylphenyl)acrylamide in 10 mL of DMF and the mixture is stirred for 48 hours at 80° C. Then the reaction mixture is poured onto water and the precipitate formed is suction filtered and washed with water. The solid is dried in the circulating air dryer at 50° C. Yield: 20 mg (10% of theory); C30H33ClN2O2 (M=489.05); melting point: 178° C.-179° C.; calc.: molecular ion peak (M+H)+: 489/491 (Cl); found: molecular ion peak (M+H)+: 489/491 (Cl).

후처리

  1. additionThen the reaction mixture is poured onto water
  2. customthe precipitate formed
  3. filtrationfiltered
  4. washwashed with water
  5. customThe solid is dried in the circulating air dryer at 50° C

출처 및 근거

ORD 기록
ord-835557360fcd43bf91259c895398a2d1
출처 데이터셋
uspto-grants-2009_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07592373B2

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