Benzyl Bromide → 2-benzyl-3-(4-methoxy-phenyl)-7-trifluoromethyl-2H-indazole

HRID 735407노트

반응식

HRID 735407 반응식
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:17]3[C:12](=[C:13]([C:18]([F:21])([F:20])[F:19])[CH:14]=[CH:15][CH:16]=3)[NH:11][N:10]=2)=[CH:5][CH:4]=1.[CH2:22](Br)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1.C(OCC)(=O)C>CN(C=O)C>[CH2:22]([N:10]1[C:9]([C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)=[C:17]2[C:12]([C:13]([C:18]([F:21])([F:19])[F:20])=[CH:14][CH:15]=[CH:16]2)=[N:11]1)[C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

참가 물질

5

반응물 3

HCID 7498Benzyl BromideHCID 8857Ethyl AcetateHCID 178489134HCID 178489134, 화합물

생성물 1

HCID 115960792-benzyl-3-(4-methoxy-phenyl)-7-trifluoromethyl-2H-indazole수율 79.8%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
120 °C

실험 절차

To a solution of 3-(4-methoxy-phenyl)-7-trifluoromethyl-1H-indazole (59 mg, 0.2 mmol) in 0.5 ml DMF were added 72 μl of benzyl bromide (0.6 mmol). The reaction mixture was heated overnight at 120° C. After cooling to room temperature, ethyl acetate was added and the solution was washed three times with brine. The organic layer was dried over MgSO4 and concentrated. Column chromatography (n-heptane/ethyl acetate, 70:30 as eluent) afforded 61 mg of pure product.

후처리

  1. temperatureAfter cooling to room temperature
  2. washthe solution was washed three times with brine
  3. dry with materialThe organic layer was dried over MgSO4
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-6122a12572e74474b1d6b2e253ddce98
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07592363B2

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