홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

4-Piperidinecarboxamide → 1-{4-[2-Benzyl-7-(trifluoromethyl)-2H-indazol-3-YL]phenyl}piperidine-4-carboxamide

HRID 735442
노트
인쇄 미리보기

반응식

HRID 735442 반응식
[CH2:1]([N:8]1[C:16]([C:17]2[CH:22]=[CH:21][C:20](Cl)=[CH:19][CH:18]=2)=[C:15]2[C:10]([C:11]([C:24]([F:27])([F:26])[F:25])=[CH:12][CH:13]=[CH:14]2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:28]1[CH2:36][CH2:35][CH:31]([C:32]([NH2:34])=[O:33])[CH2:30][CH2:29]1.C1(P(C2CCCCC2)C2C=CC=CC=2C2C=CC=CC=2N(C)C)CCCCC1.CC(C)([O-])C.[Na+]>C(COC)OC>[CH2:1]([N:8]1[C:16]([C:17]2[CH:22]=[CH:21][C:20]([N:28]3[CH2:36][CH2:35][CH:31]([C:32]([NH2:34])=[O:33])[CH2:30][CH2:29]3)=[CH:19][CH:18]=2)=[C:15]2[C:10]([C:11]([C:24]([F:27])([F:26])[F:25])=[CH:12][CH:13]=[CH:14]2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 37724-PiperidinecarboxamideHCID 27342172-(Dicyclohexylphosphino)-2'-(dimethylamino)biphenylHCID 23676156Sodium t-butoxideHCID 670211872-benzyl-3-(4-chlorophenyl)-7-(trifluoromethyl)-2H-indazole

생성물 1

HCID 115837851-{4-[2-Benzyl-7-(trifluoromethyl)-2H-indazol-3-YL]phenyl}piperidine-4-carboxamide수율 28.4%

시약·촉매·용매

1
HCID 80711,2-Dimethoxyethane용매

실험 절차

A solution of 2-benzyl-3-(4-chlorophenyl)-7-(trifluoromethyl)-2H-indazole (0.1 g, 0.25 mmol), isonipecotamide (0.039 g, 0.3 mmol), tris-(dibenzylidineacetone)dipalladium(0) (14 mg), 2-dicyclohexylphosphino-2′-(N,N-dimethylamino)biphenyl (47 mg) and sodium t-butoxide (0.029 g, 0.3 mmol) in 2 mL of dimethoxyethane was heated at 150° C. for 5 minutes in a microwave (Emory's Optimizer, Personal Chemistry). The reaction mixture was concentrated in vacuo. The residue was purified by flash chromatography (CH2Cl2-CH3OH, 19:1) to give the product (0.034 g) as an off-white solid.

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customThe residue was purified by flash chromatography (CH2Cl2-CH3OH, 19:1)

출처 및 근거

ORD 기록
ord-663709a305934b70b960e1cc39f0ad53
출처 데이터셋
uspto-grants-2009_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07592363B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트