Tetrahydrofuran → 1-(2-Benzyl-3-phenyl-2h-indazol-7-yl)ethanone

HRID 735468노트

반응식

HRID 735468 반응식
[CH2:1]([N:8]1[C:16]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:15]2[C:10](C(C(O)=O)=CC=[CH:14]2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Li][CH3:27].[CH2:28]1[CH2:32][O:31][CH2:30][CH2:29]1>>[CH2:1]([N:8]1[C:16]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[C:15]2[C:10]([C:28]([C:32](=[O:31])[CH3:27])=[CH:29][CH:30]=[CH:14]2)=[N:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

4

반응물 3

HCID 8028TetrahydrofuranHCID 67021115HCID 67021115, 화합물HCID 178418348HCID 178418348, 화합물

생성물 1

HCID 670210041-(2-Benzyl-3-phenyl-2h-indazol-7-yl)ethanone

실험 절차

2-Benzyl-3-phenyl-2H-indazole-7-carboxylic acid (0.5 mmol, 160 mg, see preparation of Example 518) was dissolved in 5 ml of dry THF at 0° C. Two milliliters (2 ml) of MeLi (1.6M solution in THF) were added dropwise and the mixture was stirred overnight at room temperature. The reaction mixture was quenched with aq NH4Cl solution and the product was extracted with EtOAc, and then flash column chromatography (SiO2, dichloromethane as an eluant) afforded 1-(2-benzyl-3-phenyl-2H-indazol-7-yl)ethanone in 61% yleld.

후처리

  1. customThe reaction mixture was quenched with aq NH4Cl solution
  2. extractionthe product was extracted with EtOAc

출처 및 근거

ORD 기록
ord-3285cf337324464392ab5406dba0c327
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07592363B2

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