Benzyl Bromide → 4-(5-(Benzyloxy)-5-oxopentyl)phenylboronic acid

반응식

[CH2:1]([O:8][C:9]([CH2:11][CH2:12][CH2:13]OC1C=CC(B(O)O)=CC=1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[B:24]([C:27]1[CH:32]=[CH:31][C:30]([CH2:33]CCCC(O)=O)=[CH:29][CH:28]=1)([OH:26])[OH:25].C(Br)C1C=CC=CC=1>>[CH2:1]([O:8][C:9](=[O:10])[CH2:11][CH2:12][CH2:13][CH2:33][C:30]1[CH:31]=[CH:32][C:27]([B:24]([OH:26])[OH:25])=[CH:28][CH:29]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

반응물 3

HCID 7498Benzyl Bromide

HCID 578426684-(3-Benzyloxycarbonyl-propoxy)-phenylboronic acid

HCID 578427605-(4-Boronophenyl)pentanoic acid

생성물 1

HCID 578426514-(5-(Benzyloxy)-5-oxopentyl)phenylboronic acid수율 79%

실험 절차

Using a procedure analogous to that used to prepare 1B, 5B (250 mg, 1.13 mmol) was reacted with benzyl bromide to afford 5C (226 mg, 79%) as a clear oil.

출처 및 근거

ORD 기록: ord-946b5f00280449e5a250e0308f917fce
출처 데이터셋: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07592331B2

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