Benzoyl chloride, 4-(hexyloxy)- → Ethyl[benzyl(4-{[4-(hexyloxy)benzoyl]amino}benzyl)amino]-(oxo)acetate

HRID 735822

반응식

HRID 735822 반응식
[CH2:1]([O:7][C:8]1[CH:16]=[CH:15][C:11]([C:12](Cl)=[O:13])=[CH:10][CH:9]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH3:6].[CH2:17]([O:19][C:20](=[O:39])[C:21]([N:23]([CH2:31][C:32]1[CH:37]=[CH:36][C:35]([NH2:38])=[CH:34][CH:33]=1)[CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:22])[CH3:18]>>[CH2:17]([O:19][C:20](=[O:39])[C:21]([N:23]([CH2:24][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)[CH2:31][C:32]1[CH:37]=[CH:36][C:35]([NH:38][C:12](=[O:13])[C:11]2[CH:15]=[CH:16][C:8]([O:7][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH3:6])=[CH:9][CH:10]=2)=[CH:34][CH:33]=1)=[O:22])[CH3:18]

참가 물질

3

반응물 2

HCID 170235Benzoyl chloride, 4-(hexyloxy)-HCID 67187687Ethyl[(4-aminobenzyl)(benzyl)amino](oxo)acetate

생성물 1

HCID 67186531Ethyl[benzyl(4-{[4-(hexyloxy)benzoyl]amino}benzyl)amino]-(oxo)acetate수율 58%

실험 절차

The same procedure as employed in the preparation of Example 15, step d but using 4-hexyloxy-benzoyl chloride and ethyl[(4-aminobenzyl)(benzyl)amino](oxo)acetate gave the title compound as a colorless oil (58%). M−(ESI): 515.2. HPLC (Condition A), Rt: 6.0 min (HPLC purity: 94.9%).

후처리

  1. customThe same procedure as employed in the preparation of Example 15, step d

출처 및 근거

ORD 기록
ord-e526092712d24841b39530a47b3d5632
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07592477B2

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