Methane → Ethyl 1,2,3,6-tetrahydroazepino[4,5-B]indole-5-carboxylate

HRID 736046

반응식

HRID 736046 반응식
Cl.[NH2:2][CH2:3][CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[NH:7][CH:6]=1.Br[CH2:15][C:16](=O)[C:17]([O:19][CH2:20][CH3:21])=[O:18].C>C(O)C>[CH2:4]1[C:5]2[C:13]3[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=3[NH:7][C:6]=2[C:16]([C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:15][NH:2][CH2:3]1

참가 물질

5

반응물 3

HCID 297MethaneHCID 66144Ethyl bromopyruvateHCID 67652Tryptamine hydrochloride

생성물 1

HCID 57467979Ethyl 1,2,3,6-tetrahydroazepino[4,5-B]indole-5-carboxylate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture of tryptamine hydrochloride (1.96 g, 10 mmol), ethyl 3-bromopyruvate (1.67 mL, 1.2 equiv) and decolorizing charcoal (0.5 g) in absolute ethanol was heated to reflux under nitrogen overnight. TEA was added and the reaction mixture was heated to reflux for another 7.5 hours. After cooling, charcoal was removed by filtration and washed with ethanol. The filtrate was concentrated under vacuum and diluted with water (20 mL). It was then extracted by EtOAc (3×30 mL) and the combined organic layers were washed with brine and dried over MgSO4. Evaporation of solvent and recrystallization from DCM-Hexane gave the title compound (1.17 g). 1H-NMR (CDCl3): δ 10.49 (1 H, br s), 7.79 (1H, d), 7.43 (1H, d), 7.43 (1H, d), 7.06 (2H, m), 5.27 (1H, br s), 4.29 (2H, q) 3.58 (2H, m), 3.17 (2H, m), 1.36 (3H, t); MS (ES): 257 (MH+).

후처리

  1. temperaturewas heated
  2. temperatureto reflux under nitrogen overnight
  3. additionTEA was added
  4. temperaturethe reaction mixture was heated
  5. temperatureto reflux for another 7.5 hours
  6. temperatureAfter cooling
  7. customcharcoal was removed by filtration
  8. washwashed with ethanol
  9. concentrationThe filtrate was concentrated under vacuum
  10. additiondiluted with water (20 mL)
  11. extractionIt was then extracted by EtOAc (3×30 mL)
  12. washthe combined organic layers were washed with brine
  13. dry with materialdried over MgSO4
  14. customEvaporation of solvent and recrystallization from DCM-Hexane

출처 및 근거

ORD 기록
ord-8328c727d4094939b885cd0720d2d3dc
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07595311B2

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