Piperazine → 3-Fluoro4-piperazin-1-yl-benzoic acid ethyl ester
반응식
[CH2:1]([O:3][C:4](=[O:13])[C:5]1[CH:10]=[CH:9][C:8](F)=[C:7]([F:12])[CH:6]=1)[CH3:2].[NH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1>CN(C)C(=O)C>[CH2:1]([O:3][C:4](=[O:13])[C:5]1[CH:10]=[CH:9][C:8]([N:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)=[C:7]([F:12])[CH:6]=1)[CH3:2]참가 물질
4
반응 조건
- 온도
- 120 °C
실험 절차
A mixture of 5 g (27 mmol) 3,4-Difluoro-benzoic acid ethyl ester and 11.56 g (134 mmol) piperazine in 15 ml N,N-dimethylacetamide was heated to 120° C. for 1.5 h and subsequently all volatiles were removed under vacuum. The residue was purified by flash column chromatography on silica eluting with DCM/methanol to yield 6.19 g (91%) of the title compound as white amorphous solid.
후처리
- customsubsequently all volatiles were removed under vacuum
- customThe residue was purified by flash column chromatography on silica eluting with DCM/methanol
출처 및 근거
- ORD 기록
- ord-d7fae6fd54b6434a871830e431eedfd9
- 출처 데이터셋
- uspto-grants-2009_09
- 특허 번호
- US07595314B2
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