Morpholine → 2-Morpholin-4-yl-5-(pyrrolidine-1-sulfonyl)-benzoic acid

HRID 736159노트

반응식

HRID 736159 반응식
CS(C1C=CC(N2CCCC2)=C(C=1)C(O)=O)(=O)=O.Cl[C:20]1[CH:28]=[CH:27][C:26]([S:29]([N:32]2[CH2:36][CH2:35][CH2:34][CH2:33]2)(=[O:31])=[O:30])=[CH:25][C:21]=1[C:22]([OH:24])=[O:23].[NH:37]1[CH2:42][CH2:41][O:40][CH2:39][CH2:38]1>>[N:37]1([C:20]2[CH:28]=[CH:27][C:26]([S:29]([N:32]3[CH2:36][CH2:35][CH2:34][CH2:33]3)(=[O:31])=[O:30])=[CH:25][C:21]=2[C:22]([OH:24])=[O:23])[CH2:42][CH2:41][O:40][CH2:39][CH2:38]1

참가 물질

4

반응물 3

HCID 8083MorpholineHCID 21198742-Chloro-5-(pyrrolidine-1-sulfonyl)benzoic acidHCID 597934895-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid

생성물 1

HCID 597937192-Morpholin-4-yl-5-(pyrrolidine-1-sulfonyl)-benzoic acid수율 34%

실험 절차

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid from 2-Chloro-5-(pyrrolidine-1-sulfonyl)-benzoic acid and morpholine and obtained in 34% yield. MS (m/e): 339.2 (MH−, 100%).

후처리

  1. customobtained in 34% yield

출처 및 근거

ORD 기록
ord-5fe328b5df27457d956e53aac50f49bc
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07595314B2

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