Morpholine → 5-(Aminosulfonyl)-2-morpholin-4-ylbenzoic acid

HRID 736218노트

반응식

HRID 736218 반응식
CS(C1C=CC(N2CCCC2)=C(C=1)C(O)=O)(=O)=O.Cl[C:20]1[CH:28]=[CH:27][C:26]([S:29](=[O:32])(=[O:31])[NH2:30])=[CH:25][C:21]=1[C:22]([OH:24])=[O:23].[NH:33]1[CH2:38][CH2:37][O:36][CH2:35][CH2:34]1>>[N:33]1([C:20]2[CH:28]=[CH:27][C:26]([S:29](=[O:32])(=[O:31])[NH2:30])=[CH:25][C:21]=2[C:22]([OH:24])=[O:23])[CH2:38][CH2:37][O:36][CH2:35][CH2:34]1

참가 물질

4

반응물 3

HCID 8083MorpholineHCID 667942-Chloro-5-aminosulfonylbenzoic acidHCID 597934895-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid

생성물 1

HCID 49621165-(Aminosulfonyl)-2-morpholin-4-ylbenzoic acid수율 85%

실험 절차

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid (Example S) from 2-Chloro-5-sulfamoyl-benzoic acid (CAS: 97-04-1; Basu; D.-G.; J. Indian Chem. Soc.; 16; 1939; 100, 106) and morpholine and obtained in 85% yield. MS (m/e): 285.1 (MH+ 100%).

후처리

  1. customobtained in 85% yield

출처 및 근거

ORD 기록
ord-08b5fe557b5d4cf6b7c1036b55011b54
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07595314B2

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