Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(6-Methoxy-cyclohex-1-enyl)-1H-indole → 3-(2-Methoxy-cyclohexyl)-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(6-Methoxy-cyclohex-1-enyl)-1H-indole | HCID 58975073 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 3-(2-Methoxy-cyclohexyl)-1H-indole | HCID 58975094 | 63% |
반응 단계
Treat 3-(6-methoxy-cyclohex-1-enyl)-1H-indole (200 mg, 0.879 mmol) with 10% Pd/C (40 mg) in EtOAc under atmospheric hydrogenation conditions for 1.5 hours. Filter resulting solution over Celite to remove catalyst. Concentrate crude on rotovap and purify on silica gel chromatography to give 3-(2-Methoxy-cyclohexyl)-1H-indole (127 mg, 63% yield). Mass Spectrum (m/e): 230.03 (MH+), 228.14 (M−).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07595339B2 |
| 출처 데이터셋 | uspto-grants-2009_09 |
| ORD ID | ord-683d20d846bf496d957543d5f33f089d |
| 출처 메모 | uspto-grants-2009_09 |