Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triphenylphosphine → 3-Cyano-2-fluoropyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | 2-Fluoronicotinamide | HCID 252367 | — |
| 용매 | Carbon Tetrachloride | HCID 5943 | — |
| 용매 | 1,1-Dichloroethane | HCID 6365 | — |
| 생성물 | 3-Cyano-2-fluoropyridine | HCID 2783254 | 64.8% |
반응 단계
Add resin bound triphenylphosphine (4.0 g, 12.0 mmol) to a solution of 2-fluoro-nicotinamide (0.6 g, 4.3 mmol) in dichloroethane (20.0 mL) and carbon tetrachloride (20.0 mL). Reflux for 18 hours, cool to RT, filter, and concentrate the filtrate under vacuum. Purify by flash column on silica gel eluting with 10-60% EtOAc in hexanes to give the title compound (0.34 g, 64%). MS (ES) 123.1 (M+1)+. 1H NMR (400 MHz, CHCl3) δ 8.46 (m, 1H), 8.09 (m, 1H), 7.37 (m, 1H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07595339B2 |
| 출처 데이터셋 | uspto-grants-2009_09 |
| ORD ID | ord-f785c08da873469b9a460065bb3c21ab |
| 출처 메모 | uspto-grants-2009_09 |