Ammonia → 5-(Aminomethyl)nicotinonitrile

HRID 736996노트

반응식

HRID 736996 반응식
Cl[CH2:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([CH:10]=1)[C:8]#[N:9].[NH3:11]>CO>[NH2:11][CH2:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([CH:10]=1)[C:8]#[N:9]

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 221467115-(Chloromethyl)pyridine-3-carbonitrile

생성물 1

HCID 200639425-(Aminomethyl)nicotinonitrile

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
80 °C

실험 절차

Dissolve 5-chloromethyl-nicotinonitrile (4.9 mg, 0.032 mmol) in 2.0M NH3 in MeOH (1 mL). Transfer this solution to a pressure tube. Heat the reaction solution at 80° C. for 2 h. Rotary evaporate the reaction solution (40° C.) to yield 5.1 mg of crude 5-aminomethyl-nicotinonitrile as a yellow oil. MS (m/e): 134.00 (M+1).

후처리

  1. customRotary evaporate the reaction solution (40° C.)

출처 및 근거

ORD 기록
ord-74cb9da3642e4a8ab7e7ac7180288e20
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07595339B2

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