Potassium Carbonate → HCID 57849627, 화합물

HRID 737109노트

반응식

HRID 737109 반응식
[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6]Br)=[CH:4][CH:3]=1.[CH:10]([CH:13]1[O:18][CH2:17][CH2:16][NH:15][CH2:14]1)([CH3:12])[CH3:11].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Br:1][C:2]1[CH:9]=[CH:8][C:5]([CH2:6][N:15]2[CH2:16][CH2:17][O:18][CH:13]([CH:10]([CH3:12])[CH3:11])[CH2:14]2)=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 685274-Bromobenzyl bromideHCID 198776882-(Propan-2-yl)morpholine

생성물 1

HCID 57849627HCID 57849627, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

The above compound could be made in the following manner: 1.5 eq. of 4-Bromobenzyl bromide and 1 eq. of 2-Isopropyl-morpholine in acetonitrile could be stirred at room temperature and 3 eq. of potassium carbonate could be added. The reaction could be stirred at room temperature overnight. The solution could be filtered through Celite and concentrated in vacuo to afford a brown solid. Purification could be done by flash chromatography to afford product.

후처리

  1. customThe reaction
  2. filtrationThe solution could be filtered through Celite
  3. concentrationconcentrated in vacuo
  4. customto afford a brown solid
  5. customPurification
  6. customto afford product

출처 및 근거

ORD 기록
ord-f76af3ff5147415eb43327fcda4bf1bd
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07595397B2

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