참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-Bromobenzyl bromide | HCID 68527 | — |
| 반응물 | 2-(Propan-2-yl)piperazine | HCID 558976 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 1-(4-Bromo-benzyl)-3-isopropyl-piperazine | HCID 57849456 | — |
반응 단계
0.7 g of 2-isopropyl-piperazine could be dissolved in acetonitrile and cooled to 0° C. A solution of 0.5 quiv. 4-bromobenzylbromide in acetonitrile could be added dropwise over 1 h. The reaction would be stirred at room temperature for 2 h. The reaction mixture could be concentrated and the residue could be purified by column chromatography (silica, eluent dichloromethane, 0-5% methanol, 0-0.5% dimethylethylamine) to afford 1-(4-bromo-benzyl)-3-isopropyl-piperazine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07595397B2 |
|---|
| 출처 데이터셋 | uspto-grants-2009_09 |
|---|
| ORD ID | ord-ab84154b14f74b55ad5a7dce6f1af402 |
|---|
| 출처 메모 | uspto-grants-2009_09 |
|---|
