Cyclopentylamine → 4-(2-Bromo-acetyl)-N-cyclopentyl-benzenesulfonamide

HRID 737193노트

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HRID 737193 반응식
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([S:11](Cl)(=[O:13])=[O:12])=[CH:7][CH:6]=1)=[O:4].C(N(CC)CC)C.[CH:22]1([NH2:27])[CH2:26][CH2:25][CH2:24][CH2:23]1>ClCCl>[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH:27][CH:22]2[CH2:26][CH2:25][CH2:24][CH2:23]2)(=[O:13])=[O:12])=[CH:7][CH:6]=1)=[O:4]

참가 물질

5

반응물 3

HCID 2906CyclopentylamineHCID 8471TriethylamineHCID 27568344-(2-bromoacetyl)benzenesulfonyl Chloride

생성물 1

HCID 866164394-(2-Bromo-acetyl)-N-cyclopentyl-benzenesulfonamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매

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온도
0 °C

실험 절차

4-(2-Bromo-acetyl)-benzenesulfonyl chloride (150 mg, 0.17 mmol) was dissolved in 4 mL of dry dichloromethane. To this solution at 0° C., was added triethylamine (0.03 mL, 0.2 mmol), followed by cyclopentylamine (0.2 mmol, 0.011 g). Reaction mixture was stirred at 0° C. for 15 minutes and then quenched with H2O. The reaction mixture was extracted with H2O. The organic phase was isolated, dried over MgSO4 and evaporated. It was used in the next step without any further purification.

후처리

  1. customReaction mixture
  2. customquenched with H2O
  3. extractionThe reaction mixture was extracted with H2O
  4. customThe organic phase was isolated
  5. dry with materialdried over MgSO4
  6. customevaporated
  7. customIt was used in the next step without any further purification

출처 및 근거

ORD 기록
ord-61fd7bb351d74546ab036ec16a3e0970
출처 데이터셋
uspto-grants-2009_09
특허 번호
US07595398B2

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