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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 73753생성일: 2026년 10월 25일

(3S)-3-Pyrrolidinemethanol → (S)-5-Bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-(hydroxymethyl)pyrrolidin-1-yl)nicotinamide

https://huagongshe.com/reaction/73753

반응식

참여 물질

역할이름HCID투입량
반응물(3S)-3-PyrrolidinemethanolHCID 7446911—
반응물5-bromo-6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)nicotinamideHCID 72546089—
생성물(S)-5-Bromo-N-(4-(chlorodifluoromethoxy)phenyl)-6-(3-(hydroxymethyl)pyrrolidin-1-yl)nicotinamideHCID 86702603—

반응 단계

The title compound was prepared in an analogous fashion to that described in Stage 9.2 using 5-bromo-6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)nicotinamide (Stage 9.3) and (S)-1-pyrrolidin-3-yl-methanol to afford an off-white crystalline solid. HPLC (Condition 4) tR5.82 min, UPLC-MS (Condition 3) tR=1.14 min, m/z=476.2/478.3 [M+H]+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08829195B2
출처 데이터셋uspto-grants-2014_09
ORD IDord-9b3cc4673186459791f4a4d561e6b87c
출처 메모uspto-grants-2014_09