5-Bromo-6-chloropyridine-3-carboxylic acid → HCID 86702611, 화합물

HRID 73766

반응식

HRID 73766 반응식
[Br:1][C:2]1[C:3]([Cl:11])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[F:12][C:13]1[CH:14]=[C:15]([CH:17]=[CH:18][C:19]=1[S:20][C:21]([F:24])([F:23])[F:22])[NH2:16]>>[Br:1][C:2]1[C:3]([Cl:11])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([NH:16][C:15]1[CH:17]=[CH:18][C:19]([S:20][C:21]([F:24])([F:22])[F:23])=[C:13]([F:12])[CH:14]=1)=[O:9]

참가 물질

3

반응물 2

HCID 2854335-Bromo-6-chloropyridine-3-carboxylic acidHCID 216143813-Fluoro-4-[(trifluoromethyl)sulfanyl]aniline

생성물 1

HCID 86702611HCID 86702611, 화합물

실험 절차

The title compound was prepared in an analogous fashion to that described in Stage 11.2 using 5-bromo-6-chloro-nicotinic acid and 3-fluoro-4-trifluoromethylsulfanyl-aniline to afford a white crystalline solid. HPLC (Condition 4) tR=6.71 min, UPLC-MS (Condition 3) tR1.34 min, m/z=429 [M−H]−.

후처리

  1. customto afford a white crystalline solid

출처 및 근거

ORD 기록
ord-af3ce584787342338c318f4976c8e16e
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829195B2

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