5-Bromo-6-chloropyridine-3-carboxylic acid → HCID 86702634, 화합물

반응식

[Br:1][C:2]1[C:3]([Cl:11])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[F:12][C:13]([F:23])([F:22])[S:14][C:15]1[N:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=1>>[Br:1][C:2]1[C:3]([Cl:11])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([NH:21][C:18]1[CH:19]=[N:20][C:15]([S:14][C:13]([F:23])([F:22])[F:12])=[CH:16][CH:17]=1)=[O:9]

참가 물질

반응물 2

HCID 2854335-Bromo-6-chloropyridine-3-carboxylic acid

HCID 436250226-[(Trifluoromethyl)sulfanyl]pyridin-3-amine

생성물 1

HCID 86702634HCID 86702634, 화합물

실험 절차

The title compound was prepared in an analogous fashion to that described in Stage 9.3 using 5-bromo-6-chloronicotinic acid and 6-(trifluoromethylthio)pyridin-3-amine to afford an off-white powder. HPLC (Condition 4) tR=6.43 min, UPLC-MS (Condition 3) tR=1.15 min, m/z=411.9 [M−H]−.

후처리

customto afford an off-white powder

출처 및 근거

ORD 기록: ord-6ee8571305a044d68682dfacec6ed401
출처 데이터셋: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08829195B2

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