Methyl 1-aminocyclohexanoate → 1-[[[4-[2-[4-(4-Morpholinyl)-1-piperazinyl]-4-thiazolyl]phenyl]carbonyl]amino]cyclohexanecarboxylic acid methyl ester
반응식
Br.[N:2]1([N:8]2[CH2:13][CH2:12][N:11]([C:14]3[S:15][CH:16]=[C:17]([C:19]4[CH:27]=[CH:26][C:22]([C:23](O)=[O:24])=[CH:21][CH:20]=4)[N:18]=3)[CH2:10][CH2:9]2)[CH2:7][CH2:6][O:5][CH2:4][CH2:3]1.[CH3:28][O:29][C:30]([C:32]1([NH2:38])[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]1)=[O:31]>>[CH3:28][O:29][C:30]([C:32]1([NH:38][C:23]([C:22]2[CH:26]=[CH:27][C:19]([C:17]3[N:18]=[C:14]([N:11]4[CH2:10][CH2:9][N:8]([N:2]5[CH2:3][CH2:4][O:5][CH2:6][CH2:7]5)[CH2:13][CH2:12]4)[S:15][CH:16]=3)=[CH:20][CH:21]=2)=[O:24])[CH2:33][CH2:34][CH2:35][CH2:36][CH2:37]1)=[O:31]참가 물질
3
실험 절차
4.50 g (9.90 mmol) of 4-[2-[4-(4-morpholinyl)-1-piperazinyl]-4-thiazolyl]benzoic acid hydrobromide was used instead of 4-[2-(4-methyl-1-piperazinyl)-4-thiazolyl]benzoic acid hydrobromide, and 1.57 g (9.90 mmol) of 1-aminocyclohexanecarboxylic acid methyl ester was used instead of 1-aminocyclohexanecarboxylic acid phenylmethyl ester in the process according to Reference Example 210 to obtain 5.08 g (quantitative) of the title compound.