Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → N-[[1-[(2-Benzothienylcarbonyl)amino]cyclohexyl]carbonyl]-L-methioninol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | L-Methioninol | HCID 2724404 | — |
| 반응물 | 2-(2-Benzothienyl)-3-oxa-1-azaspiro[4.5]dec-1-en-4-one | HCID 57672854 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-[[1-[(2-Benzothienylcarbonyl)amino]cyclohexyl]carbonyl]-L-methioninol | HCID 57672844 | 98.1% |
반응 단계
284 mg (2.1 mmol) of L-methioninol was added to a solution of 500 mg (1.75 mmol) of 2-(2-benzothienyl)-3-oxa-1-azaspiro[4.5]dec-1-en-4-one in 3 ml of N,N-dimethylformamide, and the mixture was stirred overnight. Water was slowly added and the precipitated crystal was collected by filtration. The obtained crystal was dried under reduced pressure to obtain 722 mg (98%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829209B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-9916fdb5818e47fface6418a8a6b2b93 |
| 출처 메모 | uspto-grants-2014_09 |