Benzyl Bromide → 1-benzyl-1H-indol-6-amine

HRID 73907

반응식

HRID 73907 반응식
[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([CH:8]=[CH:9][NH:10]2)=[CH:6][CH:5]=1)([O-])=O.[CH2:13](Br)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>CC#N>[CH2:13]([N:10]1[C:11]2[C:7](=[CH:6][CH:5]=[C:4]([NH2:1])[CH:12]=2)[CH:8]=[CH:9]1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

4

반응물 2

HCID 7498Benzyl BromideHCID 785026-Nitro-1H-indole

생성물 1

HCID 220195621-benzyl-1H-indol-6-amine

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

1-Benzyl-1H-indol-6-ylamine (B-2) was synthesized following the general scheme above starting from 6-nitroindole and benzyl bromide. Overall yield (˜40%). HPLC ret. time 2.19 min, 10-99% CH3CN, 5 min run; ESI-MS 223.3 m/z (MH+).

후처리

  1. customOverall yield (˜40%)

출처 및 근거

ORD 기록
ord-2f243f059f1548c0962bba11e2282422
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829204B2

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