Iodocyclopentane → 3-Cyclopentyl-1H-indol-6-ylamine

HRID 73935

반응식

HRID 73935 반응식
[N+:1]([C:4]1[CH:12]=[C:11]2[C:7]([CH:8]=[CH:9][NH:10]2)=[CH:6][CH:5]=1)([O-])=O.I[CH:14]1[CH2:18][CH2:17][CH2:16][CH2:15]1>CC#N>[CH:14]1([C:8]2[C:7]3[C:11](=[CH:12][C:4]([NH2:1])=[CH:5][CH:6]=3)[NH:10][CH:9]=2)[CH2:18][CH2:17][CH2:16][CH2:15]1

참가 물질

4

반응물 2

HCID 73784IodocyclopentaneHCID 785026-Nitro-1H-indole

생성물 1

HCID 574702013-Cyclopentyl-1H-indol-6-ylamine

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

3-Cyclopentyl-1H-indol-6-ylamine (B-15) was synthesized following the general scheme above starting from 6-nitroindole and iodo-cyclopentane. Overall yield (16%). HPLC ret. time 2.39 min, 10-99% CH3CN, 5 min run; ESI-MS 201.5 m/z (MH+).

후처리

  1. customOverall yield (16%)

출처 및 근거

ORD 기록
ord-c3c0b43630de4ff99b8c0cc7f36344df
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829204B2

연결된 노트

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