Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → beta,beta-Dimethylbenzeneethanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2-Phenylisobutyric acid | HCID 13222 | — |
| 반응물 | (Dimethyl sulfide)trihydroboron | HCID 12423031 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | beta,beta-Dimethylbenzeneethanol | HCID 219535 | 93.2% |
반응 단계
To a solution of 2-methyl-2-phenyl-propionic acid (82 g, 0.5 mol) in THF (200 mL) was added dropwise borane-dimethyl sulfide (2M, 100 mL) at 0-5° C. The mixture was stirred at this temperature for 30 min and then heated at reflux for 1 h. After cooling, methanol (150 mL) and water (50 mL) were added. The mixture was extracted with EtOAc (100 mL×3), and the combined organic layers were washed with water and brine, dried over Na2SO4 and concentrated to give 2-methyl-2-phenyl-propan-1-ol as an oil (70 g, 77%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829204B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-b19017f1db594f9c818466d35370075d |
| 출처 메모 | uspto-grants-2014_09 |