Acetic acid, 2-oxo-, methyl ester → methyl (2E)-2-[(2-chlorophenyl)hydrazinylidene]acetate

HRID 7404

반응식

HRID 7404 반응식
[C:1]([O:5][CH3:6])(=[O:4])[CH:2]=O.Cl.[Cl:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH:15][NH2:16]>CO>[Cl:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[NH:15]/[N:16]=[CH:2]/[C:1]([O:5][CH3:6])=[O:4]

참가 물질

4

반응물 2

HCID 70205Acetic acid, 2-oxo-, methyl esterHCID 4432872-Chlorophenylhydrazine hydrochloride

생성물 1

HCID 19868318methyl (2E)-2-[(2-chlorophenyl)hydrazinylidene]acetate

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of methyl glyoxylate (6.8 g, 77 mmol) in methanol (150 mL) was added 2-chlorophenylhydrazine hydrochloride (12.5 g, 77 mmol) and the mixture was heated at reflux overnight, cooled and concentrated. The residue was re-dissolved in toluene and concentrated to give the title compound of Step A.

후처리

  1. temperaturethe mixture was heated
  2. temperatureat reflux overnight
  3. temperaturecooled
  4. concentrationconcentrated
  5. dissolutionThe residue was re-dissolved in toluene
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-a1a53def4c664a96999097c0e8311779
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087598B2

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