Triethylamine → Acetamide, N-[(2-bromophenyl)methyl]-2,2,2-trifluoro-

HRID 74091

반응식

HRID 74091 반응식
[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][NH2:5].[F:10][C:11]([F:18])([F:17])[C:12](OCC)=[O:13].C(N(CC)CC)C>CO>[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][NH:5][C:12](=[O:13])[C:11]([F:18])([F:17])[F:10]

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 9794Ethyl trifluoroacetateHCID 3340722-Bromobenzylamine

생성물 1

HCID 57470274Acetamide, N-[(2-bromophenyl)methyl]-2,2,2-trifluoro-수율 103.4%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 2-bromobenzylamine (1.3 mL, 10.8 mmol) in methanol (5 mL) was added ethyl trifluoroacetate (1.54 mL, 21.6 mmol) and triethylamine (1.4 mL, 10.8 mmol) under a nitrogen atmosphere. The reaction was stirred at room temperature for 1 h. The reaction mixture was then concentrated under vacuum to yield N-(2-bromo-benzyl)-2,2,2-trifluoro-acetamide (3.15 g, quant.). HPLC ret. time 2.86 min, 10-99% CH3CN, 5 min run; ESI-MS 283.9 m/z (MH+).

후처리

  1. concentrationThe reaction mixture was then concentrated under vacuum

출처 및 근거

ORD 기록
ord-a58ea110164e4951bae5340068fc0d41
출처 데이터셋
uspto-grants-2014_09
특허 번호
US08829204B2

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