Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Pamidronic Acid → Alendronic Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Pamidronic Acid | HCID 4674 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Alendronic Acid | HCID 2088 | — |
반응 단계
The NHS ester (0.35 g, 0.62 mmol) was dissolved in H2O (30 mL), and pamidronate (0.52 g, 2.23 mmol) and Et3N (1.7 mL, 12.4 mmol) were added. The reaction solution was stirred for 24 h at room temperature. Subsequently, the H2O was removed in the vacuum. The product obtained was purified by means of HPLC.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08829233B2 |
| 출처 데이터셋 | uspto-grants-2014_09 |
| ORD ID | ord-63709912d71b4b3b8f382421cafd90e3 |
| 출처 메모 | uspto-grants-2014_09 |