Potassium Hydroxide → 4-Methoxy-3-nitrobenzoic acid

HRID 741612

반응식

HRID 741612 반응식
[N+:1]([C:4]1[C:5](C)=[C:6]([CH:10]=[CH:11][C:12]=1[O:13][CH3:14])[C:7]([O-:9])=[O:8])([O-:3])=[O:2].[OH-].[K+]>O1CCCC1>[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][C:12]=1[O:13][CH3:14])[C:7]([OH:9])=[O:8])([O-:3])=[O:2]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 189170523-Nitro-4-methoxy-methylbenzoate

생성물 1

HCID 666404-Methoxy-3-nitrobenzoic acid수율 76.6%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a 500 ml erlenmeyer flask with magnetic stirrer was charged 10.3 g of 3-nitro-4-methoxy-methylbenzoate, 400 ml tetrahydrofuran, and 3.2 g of 86% potassium hydroxide. The reaction was stirred for 12 hours at ambient temperature, after which the resulting solid was collected by vacuum filtration and washed with 2×100 ml of ethyl ether. The solid was dissolved in 200 ml of water and acidified to pH 4 with 6N hydrochloric acid. The resulting precipitate was collected by vacuum filtration, washed with 200 ml water, and dried overnight in vacuo at 30° C. Isolated 7.4 g of product as a white solid.

후처리

  1. filtrationafter which the resulting solid was collected by vacuum filtration
  2. washwashed with 2×100 ml of ethyl ether
  3. dissolutionThe solid was dissolved in 200 ml of water
  4. filtrationThe resulting precipitate was collected by vacuum filtration
  5. washwashed with 200 ml water
  6. customdried overnight in vacuo at 30° C

출처 및 근거

ORD 기록
ord-2364b5c7ac854c3ba88157643e95a9f7
출처 데이터셋
uspto-grants-1996_09
특허 번호
US05552409

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