Thiophenol → HCID 19426995, 화합물
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[F:1][C:2]1[CH:3]=[C:4]([C:9]([C:11]2[S:12][CH:13]=[CH:14][N:15]=2)=[O:10])[CH:5]=[C:6](F)[CH:7]=1.[C:16]1([SH:22])C=CC=CC=1.C[S-].[Na+].[NH4+].[Cl-]>CN(C=O)C>[CH3:16][S:22][C:6]1[CH:5]=[C:4]([C:9]([C:11]2[S:12][CH:13]=[CH:14][N:15]=2)=[O:10])[CH:3]=[C:2]([F:1])[CH:7]=1참가 물질
6
실험 절차
To a solution of (3,5-difluorophenyl)(thiazol-2-yl)methanone from Thiophenol 2, Step 2, (1.09 g, 4.84 mmol) in DMF (4.8 mL) was added sodium thiomethoxide (0.34 g, 4,84 mmol). The mixture was stirred for 4 h at r.t., then added to sat. aqueous NH4Cl (100 mL) and extracted with EtOAc. The combined organic layers were washed with brine and dried over anhydrous MgSO4. Evaporation of the solvent and chromatography using hexane:EtOAc (90:10) gave 0.80 g of the title product.
후처리
- extractionextracted with EtOAc
- washThe combined organic layers were washed with brine
- dry with materialdried over anhydrous MgSO4
- customEvaporation of the solvent and chromatography
출처 및 근거
- ORD 기록
- ord-dff2d120cf6f4053bea63183b5d15f15
- 출처 데이터셋
- uspto-grants-1996_09
- 특허 번호
- US05552437
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