Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrogen Bromide → 7-bromo-4-(bromoacetyl)-2H-chromen-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrogen Bromide | HCID 260 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | 7-bromo-4-(1-ethoxyvinyl)-2H-chromen-2-one | HCID 23370204 | — |
| 반응물 | Sodium Bisulfite | HCID 23665763 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 용매 | Acetonitrile--water (1/1) | HCID 18373917 | — |
| 생성물 | 7-bromo-4-(bromoacetyl)-2H-chromen-2-one | HCID 23370239 | — |
반응 단계
To a solution of vinyl ether from Step 1 (1.02 g) in CH3CN:H2O 4:1 (25 mL) were successively added NBS (0.82 g) and concentrated HBr (20 μL). After being stirred at r.t. for 4 h, the reaction mixture was treated with 5% aqueous NaHSO3 (1 mL). Ethyl acetate was then added and the organic phase was washed with saturated aqueous NaHCO3, H2O and brine, dried (MgSO4) and evaporated. Flash chromatography of the residue (silica gel; hexane/EtOAc (85:15)) afforded the title compound as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05552437 |
| 출처 데이터셋 | uspto-grants-1996_09 |
| ORD ID | ord-33c10a59f86a4b8dbee8b2a4e829a096 |
| 출처 메모 | uspto-grants-1996_09 |