Water → ethyl 2-(2,3-dihydro-1H-indol-1-yl)-4-[(4-fluorobenzyl)amino]-5-pyrimidinecarboxylate

HRID 7419

반응식

HRID 7419 반응식
Cl[C:2]1[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][N:5]=[C:4]([N:13]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH2:15][CH2:14]2)[N:3]=1.C(=O)([O-])[O-].[Na+].[Na+].[F:28][C:29]1[CH:36]=[CH:35][C:32]([CH2:33][NH2:34])=[CH:31][CH:30]=1.O>C(O)(C)C>[N:13]1([C:4]2[N:3]=[C:2]([NH:34][CH2:33][C:32]3[CH:35]=[CH:36][C:29]([F:28])=[CH:30][CH:31]=3)[C:7]([C:8]([O:10][CH2:11][CH3:12])=[O:9])=[CH:6][N:5]=2)[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15][CH2:14]1

참가 물질

6

반응물 4

HCID 962WaterHCID 10340Sodium CarbonateHCID 673264-FluorobenzylamineHCID 21990788ethyl 4-chloro-2-(2,3-dihydro-1H-indol-1-yl)-5-pyrimidinecarboxylate

생성물 1

HCID 21990825ethyl 2-(2,3-dihydro-1H-indol-1-yl)-4-[(4-fluorobenzyl)amino]-5-pyrimidinecarboxylate수율 81.2%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

To a solution of ethyl 4-chloro-2-(2,3-dihydro-1H-indol-1-yl)-5-pyrimidinecarboxylate (607 mg, 2.0 mmol) in isopropanol (5 mL) were added sodium carbonate (424 mg, 4 mmol) and 4-fluorobenzylamine (313 mg, 4 mmol) and the mixture was heated under reflux for 18 h. The reaction mixture was allowed to cool to room temperature and water was added. The precipitated crystals were collected by filtration, washed several times with cold water and cold ether and dried to give the title compound (637 mg, 81%).

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 18 h
  3. filtrationThe precipitated crystals were collected by filtration
  4. washwashed several times with cold water and cold ether
  5. customdried

출처 및 근거

ORD 기록
ord-a61417b4a55b431fb3b5c4a7891ca0c1
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07087597B1

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